Description
PLAGL1 Antibody (PACO61690)
The Plagl1 Polyclonal Antibody (PAC061690) is a specialized tool for researchers studying the Plagl1 protein, a transcription factor involved in various cellular processes, including growth and development. This antibody, generated in rabbits, exhibits high specificity and reactivity towards human samples, making it a reliable tool for Western blot applications. By binding to the Plagl1 protein, this antibody allows for accurate detection and analysis in a wide range of cell types, making it a valuable asset for studies in molecular biology and developmental biology.
Plagl1, also known as Zinc finger protein PLAGL1, plays a crucial role in regulating gene expression and controlling cell proliferation, differentiation, and apoptosis. Its importance in cellular processes makes it a key target for research in areas such as cancer biology, developmental disorders, and stem cell biology. By understanding the function and regulation of Plagl1, researchers can gain insights into the mechanisms underlying various diseases and potentially identify new therapeutic targets for intervention.
| Antibody Name: | PLAGL1 Antibody (PACO61690) |
| Antibody SKU: | PACO61690 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Zinc finger protein PLAGL1 protein (237-372AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, 293 whole cell lysate, 293T whole cell lysate, HepG2 whole cell lysate, SH-SY5Y whole cell lysate, A549 whole cell lysate. All lanes: PLAGL1 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 51, 45 kDa. Observed band size: 51 kDa. |
| Background: | Shows weak transcriptional activatory activity. Transcriptional regulator of the type 1 receptor for pituitary adenylate cyclase-activating polypeptide. |
| Synonyms: | Zinc finger protein PLAGL1, Lost on transformation 1, LOT-1, Pleiomorphic adenoma-like protein 1, Tumor suppressor ZAC, PLAGL1, LOT1, ZAC |
| UniProt Protein Function: | PLAGL1: Shows weak transcriptional activatory activity. Transcriptional regulator of the type 1 receptor for pituitary adenylate cyclase-activating polypeptide. Belongs to the krueppel C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; C2H2-type zinc finger protein Chromosomal Location of Human Ortholog: 6q24-q25 Cellular Component: Golgi apparatus; intracellular membrane-bound organelle; nucleoplasm; nucleus Molecular Function:DNA binding Biological Process: apoptosis; cell cycle arrest; cell differentiation; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; positive regulation of transcription from RNA polymerase II promoter Disease: Diabetes Mellitus, Transient Neonatal, 1 |
| NCBI Summary: | This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM). Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding two different protein isoforms. The P1 downstream promoter of this gene is imprinted, with preferential expression from the paternal allele in many tissues. [provided by RefSeq, Nov 2015] |
| UniProt Code: | Q9UM63 |
| NCBI GenInfo Identifier: | 158523334 |
| NCBI Gene ID: | 5325 |
| NCBI Accession: | Q9UM63.2 |
| UniProt Secondary Accession: | Q9UM63,O76019, Q7Z3V8, Q92981, Q96JR9, Q9UIZ0, B2RBA4 B2RCM8, E1P595, E1P597, |
| UniProt Related Accession: | Q9UM63 |
| Molecular Weight: | 44,668 Da |
| NCBI Full Name: | Zinc finger protein PLAGL1 |
| NCBI Synonym Full Names: | PLAG1 like zinc finger 1 |
| NCBI Official Symbol: | PLAGL1Â Â |
| NCBI Official Synonym Symbols: | ZAC; LOT1; ZAC1Â Â |
| NCBI Protein Information: | zinc finger protein PLAGL1 |
| UniProt Protein Name: | Zinc finger protein PLAGL1 |
| UniProt Synonym Protein Names: | Lost on transformation 1; LOT-1; Pleiomorphic adenoma-like protein 1; Tumor suppressor ZAC |
| Protein Family: | Zinc finger protein |
| UniProt Gene Name: | PLAGL1Â Â |
| UniProt Entry Name: | PLAL1_HUMAN |
| Antibodies |
| PLAGL1 Antibody (PACO01713) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
