The PLCD1 Polyclonal Antibody (PAC011287) is a valuable tool for researchers investigating the role of PLCD1 in cellular signaling pathways. PLCD1, also known as phospholipase C delta 1, is involved in intracellular signaling cascades, particularly in response to extracellular stimuli. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it a reliable choice for Western blot analysis. By targeting the PLCD1 protein, researchers can gain insights into its function in various cell types, aiding in the study of signal transduction and cell communication processes.
PLCD1 is known to play a role in diverse biological processes, including cell proliferation, differentiation, and cell cycle regulation. Its dysregulation has been implicated in various diseases, such as cancer and cardiovascular disorders. By employing the PLCD1 Polyclonal Antibody, researchers can uncover novel pathways and potential therapeutic targets for these conditions, advancing our understanding of PLCD1's role in health and disease.
PLCD1: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development. Defects in PLCD1 are the cause of nail disorder non- syndromic congenital type 3 (NDNC3). NDNC3 is a nail disorder characterized by a white appearance of the nail plate (true leukonychia), the nail bed (pseudoleukonychia), or neither (apparent leukonychia). Leukonychia may involve all of the nail (leukonychia totalis) or only part of the nail (leukonychia partialis), or can appear as one or more transverse bands (leukonychia striata) or white spots (leukonychia punctata). 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.1.4.11; Carbohydrate Metabolism - inositol phosphate; PhospholipaseChromosomal Location of Human Ortholog: 3p22-p21.3Cellular Component: cytoplasm; plasma membrane; cytosolMolecular Function: signal transducer activity; phosphatidylserine binding; GTPase activating protein binding; calcium ion binding; phosphoinositide phospholipase C activityBiological Process: inositol phosphate metabolic process; phospholipid metabolic process; angiogenesis; lipid catabolic process; regulation of cell proliferationDisease: Nail Disorder, Nonsyndromic Congenital, 3
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
