The Plekhf1 Polyclonal Antibody (PACO11299) is a valuable tool for researchers studying Plekhf1, a protein involved in various cellular processes, including autophagy and lysosomal function. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards Plekhf1 in human samples, making it suitable for use in Western blot applications. By binding to Plekhf1, this antibody enables accurate detection and analysis of the protein in different cell types, making it an essential tool for investigations in cell biology and molecular research.Plekhf1, also known as Pleckstrin Homology Domain Containing Family F Member 1, plays a crucial role in regulating autophagy, a key process in maintaining cellular homeostasis and responding to stress conditions.
Dysregulation of autophagy has been implicated in various diseases, including neurodegenerative disorders and cancer, highlighting the significance of studying proteins like Plekhf1. By delving into the function and mechanisms of Plekhf1, researchers can gain insights that may lead to the development of novel therapeutic strategies for addressing autophagy-related diseases.
pleckstrin homology domain containing, family F (with FYVE domain) member 1;PLEKHF1;APPD;MGC4090;PHAFIN1;ZFYVE15 ;
UniProt Protein Function:
PKHF1: May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase- independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8.Chromosomal Location of Human Ortholog: 19q12Cellular Component: endosome; endosome membrane; lysosomal membrane; lysosomeMolecular Function: phosphatidylinositol 3-phosphate binding; phosphatidylinositol-5-phosphate binding; protein bindingBiological Process: endosome organization and biogenesis; positive regulation of autophagy; vesicle organization and biogenesis
Pleckstrin homology domain-containing family F member 1
NCBI Synonym Full Names:
pleckstrin homology and FYVE domain containing 1
NCBI Official Symbol:
PLEKHF1Â Â
NCBI Official Synonym Symbols:
APPD; LAPF; PHAFIN1; ZFYVE15Â Â
NCBI Protein Information:
pleckstrin homology domain-containing family F member 1
UniProt Protein Name:
Pleckstrin homology domain-containing family F member 1
UniProt Synonym Protein Names:
Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains; Apoptosis-inducing protein; PH and FYVE domain-containing protein 1; Phafin-1; Zinc finger FYVE domain-containing protein 15
