Description
PLPP2 Antibody (PACO29100)
The PLPP2 Polyclonal Antibody (PAC029100) is a valuable tool for research involving PLPP2, a key enzyme involved in lipid metabolism and cell signaling pathways. This antibody is produced in rabbits and exhibits high reactivity with human samples, making it ideal for use in Western blot applications. By binding to the PLPP2 protein, this antibody enables the detection and analysis of PLPP2 in various cell types, offering researchers valuable insights into lipid metabolism and cellular signaling mechanisms.PLPP2, also known as phospholipid phosphatase 2, plays a crucial role in maintaining lipid homeostasis and modulating cellular responses to extracellular signals.
Dysregulation of PLPP2 activity has been implicated in various diseases, including cancer, metabolic disorders, and neurodegenerative conditions. By studying the function of PLPP2, researchers can uncover new therapeutic targets and develop interventions to treat these diseases.Overall, the PLPP2 Polyclonal Antibody is a versatile tool for investigating the role of PLPP2 in diverse physiological and pathological processes. Its high specificity and sensitivity make it a valuable asset for researchers in the fields of lipid biology, cell signaling, and disease mechanisms.
| Antibody Name: | PLPP2 Antibody (PACO29100) |
| Antibody SKU: | PACO29100 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Phospholipid phosphatase 2 protein (109-162AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: PLPP2 antibody at 8µg/ml + MCF-7 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 33, 35, 27 kDa Observed band size: 33 kDa . |
 | Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO29100 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO29100 at dilution of 1:100. |
| Background: | Catalyzes the conversion of phosphatidic acid, (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid, (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P. |
| Synonyms: | Phospholipid phosphatase 2 (EC 3.1.3.4) (Lipid phosphate phosphohydrolase 2) (PAP2-gamma) (PAP2-G) (Phosphatidate phosphohydrolase type 2c) (Phosphatidic acid, phosphatase 2c) (PAP-2c) (PAP2c), PLPP2, LPP2 PPAP2C |
| UniProt Protein Function: | PPAP2C: Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P. Belongs to the PA-phosphatase related phosphoesterase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Lipid Metabolism - ether lipid; Motility/polarity/chemotaxis; Membrane protein, multi-pass; EC 3.1.3.4; Lipid Metabolism - glycerolipid; Phosphatase, lipid; Membrane protein, integral; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - sphingolipidChromosomal Location of Human Ortholog: 19p13Cellular Component: integral to plasma membrane; membrane; plasma membraneMolecular Function: lipid phosphatase activity; phosphoprotein phosphatase activity; protein binding; sphingosine-1-phosphate phosphatase activityBiological Process: phospholipid dephosphorylation; phospholipid metabolic process; signal transduction; sphingolipid biosynthetic process |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43688 |
| NCBI GenInfo Identifier: | 45504419 |
| NCBI Gene ID: | 8612 |
| NCBI Accession: | O43688.1 |
| UniProt Secondary Accession: | O43688,A6NLV0, E9PAY8 |
| UniProt Related Accession: | O43688 |
| Molecular Weight: | 26,103 Da |
| NCBI Full Name: | Phospholipid phosphatase 2 |
| NCBI Synonym Full Names: | phospholipid phosphatase 2 |
| NCBI Official Symbol: | PLPP2Â Â |
| NCBI Official Synonym Symbols: | LPP2; PAP-2c; PAP2-g; PPAP2CÂ Â |
| NCBI Protein Information: | phospholipid phosphatase 2 |
| UniProt Protein Name: | Phospholipid phosphatase 2 |
| UniProt Synonym Protein Names: | Lipid phosphate phosphohydrolase 2; PAP2-gamma; PAP2-G; Phosphatidate phosphohydrolase type 2c; Phosphatidic acid phosphatase 2c; PAP-2c; PAP2c |
| Protein Family: | |
| UniProt Gene Name: | PLPP2Â Â |
| UniProt Entry Name: | PLPP2_HUMAN |
