The PMS1 Antibody (CAB2183) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the PMS1 protein, this antibody allows for the detection and analysis of PMS1 in a variety of cell types, making it well-suited for studies in genetics, cancer research, and other fields where DNA repair mechanisms are of interest.PMS1 is essential for maintaining the integrity of the genome by correcting errors that occur during DNA replication, making it a critical factor in preventing mutations that can lead to cancer and other diseases.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
Product Name:
PMS1 Antibody
SKU:
CAB2183
Size:
20μL, 100μL
Reactivity:
Human
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
MLH2, PMSL1, hPMS1, HNPCC3, PMS1
Positive Sample:
HL-60, MCF7, HT-1080
Cellular Localization:
Nucleus.
Calculated MW:
106kDa
Observed MW:
110kDa
This gene encodes a protein belonging to the DNA mismatch repair mutL/hexB family. This protein is thought to be involved in the repair of DNA mismatches, and it can form heterodimers with MLH1, a known DNA mismatch repair protein. Mutations in this gene cause hereditary nonpolyposis colorectal cancer type 3 (HNPCC3) either alone or in combination with mutations in other genes involved in the HNPCC phenotype, which is also known as Lynch syndrome.
Purification Method
Affinity purification
Gene ID
5378
RRID
AB_2764201
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using PMS1 Rabbit pAb (CAB2183) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 5s.
