Description
PNCK Antibody (PACO03503)
The PNCK Polyclonal Antibody (PAC003503) is a vital tool for researchers studying PNCK, a protein kinase involved in various cellular processes such as cell signaling and proliferation. This antibody, produced in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications. By binding to the PNCK protein, this antibody enables precise detection and analysis in a wide range of cell types, making it an ideal choice for studies in cell biology and cancer research.PNCK, a member of the protein kinase C (PKC) family, is known to play a pivotal role in regulating cellular functions such as cell growth and differentiation.
Its involvement in key signaling pathways makes it a promising target for research aimed at understanding diseases like cancer, where abnormal cell proliferation and signaling are common features. By elucidating the role of PNCK in disease pathology, researchers can uncover new therapeutic strategies that target this kinase for potential treatment options.
| Antibody Name: | PNCK Antibody |
| Antibody SKU: | PACO03503 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the Internal region of human CaMKIBeta. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | PNCK; Calcium/calmodulin-dependent protein kinase type 1B; CaM kinase I beta; CaM kinase IB; CaM-KI beta; CaMKI-beta; Pregnancy up-regulated non-ubiquitously-expressed CaM kinase |
| UniProt Protein Function: | CAMK1B: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; EC 2.7.11.17; CAMK group; CAMK1 family Chromosomal Location of Human Ortholog: Xq28 |
| NCBI Summary: | PNCK is a member of the calcium/calmodulin-dependent protein kinase family of protein serine/threonine kinases (see CAMK1; MIM 604998) (Gardner et al., 2000 [PubMed 10673339]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q6P2M8 |
| NCBI GenInfo Identifier: | 67466915 |
| NCBI Gene ID: | 139728 |
| NCBI Accession: | Q6P2M8.2 |
| UniProt Secondary Accession: | Q6P2M8,Q8N4R0, B4DJR8, B4E1A6, B7WPG0, D3DWU7, |
| UniProt Related Accession: | Q6P2M8 |
| Molecular Weight: | 40,356 Da |
| NCBI Full Name: | Calcium/calmodulin-dependent protein kinase type 1B |
| NCBI Synonym Full Names: | pregnancy up-regulated nonubiquitous CaM kinase |
| NCBI Official Symbol: | PNCKÂ Â |
| NCBI Official Synonym Symbols: | BSTK3; CaMK1b  |
| NCBI Protein Information: | calcium/calmodulin-dependent protein kinase type 1B |
| UniProt Protein Name: | Calcium/calmodulin-dependent protein kinase type 1B |
| UniProt Synonym Protein Names: | CaM kinase I beta; CaM kinase IB; CaM-KI beta; CaMKI-beta; Pregnancy up-regulated non-ubiquitously-expressed CaM kinase |
| Protein Family: | Calcium/calmodulin-dependent protein kinase |
| UniProt Gene Name: | PNCKÂ Â |
| UniProt Entry Name: | KCC1B_HUMAN |
