The PNKD Polyclonal Antibody (CAB8203) is a vital tool for researchers studying PNKD, a protein associated with paroxysmal nonkinesigenic dyskinesia, a rare neurological movement disorder. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been extensively validated for use in Western blot applications. By binding specifically to the PNKD protein, this antibody enables precise detection and analysis in various cell types, making it an essential component for studies in neurology and movement disorders.PNKD, a gene encoding the protein paroxysmal nonkinesigenic dyskinesia, is involved in the regulation of movement control and coordination in the brain.
Mutations in the PNKD gene can lead to abnormal movements and involuntary muscle contractions, resulting in symptoms characteristic of paroxysmal dyskinesias. Research on PNKD is crucial for understanding the mechanisms underlying movement disorders and developing potential therapeutic interventions to alleviate symptoms and improve patient outcomes. The PNKD Polyclonal Antibody (CAB8203) offers a reliable tool for researchers to investigate the role of PNKD in health and disease, paving the way for advancements in neurological research and patient care.
Product Name:
PNKD Rabbit Polyclonal Antibody
SKU:
CAB8203
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human PNKD (NP_056303.3).
This gene is thought to play a role in the regulation of myofibrillogenesis. Mutations in this gene have been associated with the movement disorder paroxysmal non-kinesigenic dyskinesia. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
25953
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PNKD antibody (CAB8203) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
