Based on the information provided in the URL, a product description for the Polr3D Antibody (PAC05097) could be:The Polr3D Polyclonal Antibody (PAC05097) is a valuable tool for researchers studying Polr3D, a subunit of RNA polymerase III involved in transcription. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blotting. By specifically binding to the Polr3D protein, this antibody enables accurate detection and analysis in different cell types, making it an essential component of studies in molecular biology and gene expression regulation.
Polr3D is a key player in RNA polymerase III activity, which is crucial for synthesizing small RNA molecules involved in various cellular processes. Understanding the function and regulation of Polr3D is essential for deciphering the mechanisms underlying gene expression and transcriptional control. Research into Polr3D may provide insights into diseases related to RNA metabolism and genetic regulation, making this antibody a valuable resource for scientists exploring these areas of study.
Antibody Name:
POLR3D Antibody (PACO05097)
Antibody SKU:
PACO05097
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:40000, WB:1:500-1:2000
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from the C-terminal region of human POLR3D.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
POLR3D; BN51; BN51T; DNA-directed RNA polymerase III subunit RPC4; RNA polymerase III subunit C4; DNA-directed RNA polymerase III subunit D; Protein BN51; RNA polymerase III 47 kDa subunit; RPC53 homolog
UniProt Protein Function:
POLR3D: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Belongs to the eukaryotic RPC4/POLR3D RNA polymerase subunit family.Protein type: Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidineChromosomal Location of Human Ortholog: 8q21Cellular Component: cytosol; DNA-directed RNA polymerase III complex; nuclear chromatin; nucleoplasmBiological Process: positive regulation of innate immune response; positive regulation of interferon type I production; positive regulation of interferon-beta production
UniProt Protein Details:
NCBI Summary:
This gene complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line. It leads to a block in progression through the G1 phase of the cell cycle at nonpermissive temperatures. [provided by RefSeq, Jul 2008]
