The Polr3D Polyclonal Antibody (PACO11364) is a powerful tool for researchers studying RNA polymerase III subunit D (POLR3D), a key component of the RNA polymerase III complex involved in transcription. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting POLR3D in human samples, making it a reliable choice for Western blot applications.POLR3D is essential for the transcription of small non-coding RNAs, including transfer RNAs (tRNAs) and 5S ribosomal RNA. Dysregulation of POLR3D has been linked to various diseases, such as hypomyelinating leukodystrophy and neurodevelopmental disorders.
By targeting POLR3D with this antibody, researchers can investigate its role in transcription and its implications for human health.Overall, the Polr3D Polyclonal Antibody (PACO11364) offers a valuable tool for studying POLR3D function and its involvement in transcriptional processes, providing insights into molecular mechanisms underlying RNA polymerase III activity. It is a must-have for any laboratory conducting research in the fields of molecular biology, genetics, and neurology.
polymerase (RNA) III (DNA directed) polypeptide D, 44kDa;POLR3D;BN51T;RPC4;RPC53;TSBN51 ;
UniProt Protein Function:
POLR3D: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Belongs to the eukaryotic RPC4/POLR3D RNA polymerase subunit family.Protein type: Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidineChromosomal Location of Human Ortholog: 8q21Cellular Component: cytosol; DNA-directed RNA polymerase III complex; nuclear chromatin; nucleoplasmBiological Process: positive regulation of innate immune response; positive regulation of interferon type I production; positive regulation of interferon-beta production
UniProt Protein Details:
NCBI Summary:
This gene complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line. It leads to a block in progression through the G1 phase of the cell cycle at nonpermissive temperatures. [provided by RefSeq, Jul 2008]
