The PPAP2C Polyclonal Antibody (PACO18809) is a valuable tool for research involving PPAP2C, a key enzyme involved in lipid metabolism and signal transduction pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the PPAP2C protein, this antibody enables precise detection and analysis in a variety of cell types, making it an ideal choice for studies in lipid biology, metabolism, and cell signaling.PPAP2C, also known as lipid phosphate phosphohydrolase 2, plays a pivotal role in regulating lipid signaling molecules, which are essential for cell growth, proliferation, and survival.
Dysregulation of PPAP2C activity has been linked to various diseases, including cancer, metabolic disorders, and inflammatory conditions. Therefore, the study of PPAP2C function is crucial for unraveling the mechanisms underlying these diseases and developing targeted therapies.By utilizing the PPAP2C Polyclonal Antibody (PACO18809), researchers can gain valuable insights into the role of PPAP2C in cellular processes and disease pathogenesis, ultimately contributing to the advancement of therapeutic strategies targeting lipid metabolism and signal transduction pathways.
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO18809(PPAP2C Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse trachea tissue, Primary antibody: PACO18809(PPAP2C Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO18809(PPAP2C Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene is a member of the phosphatidic acid, phosphatase (PAP) family. PAPs convert phosphatidic acid, to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid, phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
Synonyms:
Phosphatidic acid, phosphatase type 2C
UniProt Protein Function:
PPAP2C: Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P. Belongs to the PA-phosphatase related phosphoesterase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Lipid Metabolism - ether lipid; Motility/polarity/chemotaxis; Membrane protein, multi-pass; EC 3.1.3.4; Lipid Metabolism - glycerolipid; Phosphatase, lipid; Membrane protein, integral; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - sphingolipidChromosomal Location of Human Ortholog: 19p13Cellular Component: integral to plasma membrane; membrane; plasma membraneMolecular Function: lipid phosphatase activity; phosphoprotein phosphatase activity; protein binding; sphingosine-1-phosphate phosphatase activityBiological Process: phospholipid dephosphorylation; phospholipid metabolic process; signal transduction; sphingolipid biosynthetic process
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
