The PPP1R11 Polyclonal Antibody (PACO05185) is a valuable tool for researchers studying PPP1R11, a protein phosphatase 1 regulatory subunit that plays a role in cell cycle regulation and apoptosis. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blotting applications. By binding specifically to PPP1R11, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in cell biology and cancer research.
PPP1R11 is known to interact with protein phosphatase 1 (PP1) to regulate various cellular processes such as cell division and programmed cell death. Dysregulation of PPP1R11 has been implicated in cancer development and progression, highlighting its potential as a therapeutic target for anti-cancer strategies. By studying the function of PPP1R11, researchers can gain insights into the mechanisms underlying tumorigenesis and identify new therapeutic avenues for cancer treatment.
Antibody Name:
PPP1R11 Antibody (PACO05185)
Antibody SKU:
PACO05185
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:40000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthesized peptide derived from the Internal region of human Tctex5.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
PPP1R11; HCGV; TCTE5; Protein phosphatase 1 regulatory subunit 11; Hemochromatosis candidate gene V protein; HCG V; Protein phosphatase inhibitor 3
UniProt Protein Function:
PPP1R11: Inhibitor of protein phosphatase 1.Protein type: Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunitChromosomal Location of Human Ortholog: 6p22.1Cellular Component: cytoplasm; nucleus; protein phosphatase type 1 complexMolecular Function: protein binding; protein phosphatase 1 binding; type 1 serine/threonine specific protein phosphatase inhibitor activityBiological Process: negative regulation of phosphoprotein phosphatase activity
UniProt Protein Details:
NCBI Summary:
This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6. [provided by RefSeq, Jul 2008]
