Description
PPP1R14C Antibody (PACO00997)
The PPP1R14C Polyclonal Antibody (PACO00997) is an essential tool for researchers studying the PPP1R14C protein, which plays a key role in cell cycle regulation and cell proliferation. Raised in rabbits, this antibody demonstrates high reactivity with human samples and has been validated for use in applications such as Western blotting.PPP1R14C, also known as protein phosphatase 1 regulatory subunit 14C, is involved in the dephosphorylation of target proteins, leading to the regulation of various cellular processes. Its function in cell cycle progression and proliferation makes it a crucial target for research in fields such as cancer biology, cell signaling, and developmental biology.
By detecting and analyzing PPP1R14C expression in different cell types, this antibody aids in understanding the protein's role in these processes.Furthermore, studying PPP1R14C can provide insights into potential therapeutic targets for diseases characterized by dysregulated cell growth, such as cancer. By unraveling the mechanisms by which PPP1R14C influences cell proliferation, researchers can develop targeted interventions to modulate these processes and potentially design novel treatment strategies.
| Antibody Name: | PPP1R14C Antibody |
| Antibody SKU: | PACO00997 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the Internal region of human KEPI. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | PPP1R14C; KEPI; Protein phosphatase 1 regulatory subunit 14C; Kinase-enhanced PP1 inhibitor; PKC-potentiated PP1 inhibitory protein; Serologically defined breast cancer antigen NY-BR-81 |
| UniProt Protein Function: | KEPI: Inhibitor of PPP1CA. Has over 600-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. Belongs to the PP1 inhibitor family. |
| UniProt Protein Details: | Protein type:Inhibitor; Protein phosphatase, regulatory subunit Chromosomal Location of Human Ortholog: 6q24.3-q25.3 Cellular Component: cytoplasm; membrane Molecular Function:type 1 serine/threonine specific protein phosphatase inhibitor activity Biological Process: negative regulation of catalytic activity; regulation of phosphorylation |
| NCBI Summary: | The degree of protein phosphorylation is regulated by a balance of protein kinase and phosphatase activities. Protein phosphatase-1 (PP1; see MIM 176875) is a signal-transducing phosphatase that influences neuronal activity, protein synthesis, metabolism, muscle contraction, and cell division. PPP1R14C is an inhibitor of PP1 (Liu et al., 2002 [PubMed 11812771]).[supplied by OMIM, Feb 2010] |
| UniProt Code: | Q8TAE6 |
| NCBI GenInfo Identifier: | 90110047 |
| NCBI Gene ID: | 81706 |
| NCBI Accession: | Q8TAE6.3 |
| UniProt Secondary Accession: | Q8TAE6,Q5VY83, Q96BB1, Q9H277, |
| UniProt Related Accession: | Q8TAE6 |
| Molecular Weight: | 17,843 Da |
| NCBI Full Name: | Protein phosphatase 1 regulatory subunit 14C |
| NCBI Synonym Full Names: | protein phosphatase 1 regulatory inhibitor subunit 14C |
| NCBI Official Symbol: | PPP1R14CÂ Â |
| NCBI Official Synonym Symbols: | KEPI; NY-BR-81; CPI17-like  |
| NCBI Protein Information: | protein phosphatase 1 regulatory subunit 14C |
| UniProt Protein Name: | Protein phosphatase 1 regulatory subunit 14C |
| UniProt Synonym Protein Names: | Kinase-enhanced PP1 inhibitor; PKC-potentiated PP1 inhibitory protein; Serologically defined breast cancer antigen NY-BR-81 |
| Protein Family: | Protein phosphatase 1 regulatory |
| UniProt Gene Name: | PPP1R14CÂ Â |
| UniProt Entry Name: | PP14C_HUMAN |
