The PPP1R14D Polyclonal Antibody (PACO01358) is a valuable tool for researchers studying PPP1R14D, a protein phosphatase that plays a key role in regulating various cellular processes. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the PPP1R14D protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an essential component for studies in cell signaling and molecular biology.
PPP1R14D is known for its involvement in the regulation of smooth muscle contraction and cell proliferation, making it a potential target for research in cardiovascular diseases, muscle disorders, and cancer. By understanding the function and activity of PPP1R14D, researchers can gain insights into the mechanisms underlying these conditions and potentially develop therapeutic strategies to target PPP1R14D for clinical applications.
Antibody Name:
PPP1R14D Antibody
Antibody SKU:
PACO01358
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human PPP1R14D.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
PPP1R14D; GBPI; Protein phosphatase 1 regulatory subunit 14D; Gastrointestinal and brain-specific PP1-inhibitory protein 1; GBPI-1
UniProt Protein Function:
GBPI-1: Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. Belongs to the PP1 inhibitor family.Protein type: Inhibitor; Protein phosphatase, regulatory subunitChromosomal Location of Human Ortholog: 15q15.1Cellular Component: cytoplasmMolecular Function: protein phosphatase inhibitor activityBiological Process: regulation of phosphorylation; negative regulation of catalytic activity
UniProt Protein Details:
NCBI Summary:
Protein phosphatase-1 (PP1; see MIM 176875) is a major cellular phosphatase that reverses serine/threonine protein phosphorylation. PPP1R14D is a PP1 inhibitor that itself is regulated by phosphorylation (Liu et al., 2004 [PubMed 12974676]).[supplied by OMIM, Feb 2010]
protein phosphatase 1 regulatory subunit 14D isoform 1
NCBI Synonym Full Names:
protein phosphatase 1, regulatory (inhibitor) subunit 14D
NCBI Official Symbol:
PPP1R14DÂ Â
NCBI Official Synonym Symbols:
GBPI1; GBPI-1; CPI17-like Â
NCBI Protein Information:
protein phosphatase 1 regulatory subunit 14D; PKC-dependent PP1 inhibitory protein; gut and brain phosphatase inhibitor 1; gastrointestinal and brain-specific PP1-inhibitory protein 1
UniProt Protein Name:
Protein phosphatase 1 regulatory subunit 14D
UniProt Synonym Protein Names:
Gastrointestinal and brain-specific PP1-inhibitory protein 1
