The PRDM4 Antibody (PAC042354) is a valuable tool for researchers studying the PRDM4 protein, a transcription factor implicated in various cellular processes such as cell differentiation and development. This polyclonal antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications.PRDM4, also known as PR domain zinc finger protein 4, plays a crucial role in gene regulation and cell growth, making it a promising target for research in fields such as developmental biology and cancer biology. By binding specifically to the PRDM4 protein, this antibody enables sensitive detection and analysis in different cell types, facilitating in-depth studies on the functions and mechanisms of PRDM4.
The PRDM4 Antibody is essential for investigating the role of PRDM4 in cellular processes and disease pathways, offering insights that could lead to potential therapeutic strategies in conditions where dysregulation of PRDM4 is implicated. With its versatility and specificity, this antibody is a valuable asset for researchers seeking to advance their understanding of PRDM4 biology.
Western Blot. Positive WB detected in: Hela whole cell lysate, Mouse lung tissue, Mouse kidney tissue, Mouse skeletal muscle tissue. All lanes: PRDM4 antibody at 3.4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 88 kDa. Observed band size: 88, 70 kDa.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO42354 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO42354 at dilution of 1:100.
Background:
May function as a transcription factor involved in cell differentiation.
Synonyms:
PR domain zinc finger protein 4 (EC 2.1.1.-) (PR domain-containing protein 4), PRDM4, PFM1
UniProt Protein Function:
PRDM4: May function as a transcription factor involved in cell differentiation.Protein type: Methyltransferase, protein lysine, predicted; C2H2-type zinc finger proteinChromosomal Location of Human Ortholog: 12q23-q24.1Cellular Component: nucleusMolecular Function: methyltransferase activity; DNA binding; zinc ion bindingBiological Process: transcription from RNA polymerase II promoter; methylation; cell proliferation; nerve growth factor receptor signaling pathway; regulation of transcription, DNA-dependent; signal transduction; negative regulation of cell cycle
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. An elevated expression level of this gene has been observed in PC12 cells treated with nerve growth factor, beta polypeptide (NGF). This gene is located in a chromosomal region that is thought to contain tumor suppressor genes. [provided by RefSeq, Jul 2008]
