Anti-PRMT7 Antibody (CAB17164)
- SKU:
- CAB17164
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
| Antibody Name: | Anti-PRMT7 Antibody |
| Antibody SKU: | CAB17164 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 513-692 of human PRMT7 (NP_061896.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 513-692 of human PRMT7 (NP_061896.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QAAS LHAV VVEF RDLW RIRS PCGD CEGF DVHI MDDM IKRA LDFR ESRE AEPH PLWE YPCR SLSE PWQI LTFD FQQP VPLQ PLCA EGTV ELRR PGQS HAAV LWME YHLT PECT LSTG LLEP ADPE GGCC WNPH CKQA VYFF SPAP DPRA LLGG PRTV SYAV EFHP DTGD IIME FRHA DTPD |
| Gene ID: | 54496 |
| Uniprot: | Q9NVM4 |
| Cellular Location: | |
| Calculated MW: | 62kDa/63kDa/73kDa/78kDa |
| Observed MW: | Refer to figures |
 | Immunohistochemistry - PRMT7 Polyclonal Antibody (CAB17164) |
| Synonyms: | PRMT7, SBIDDS |
| Background: | Arginine methylation is an apparently irreversible protein modification catalyzed by arginine methyltransferases, such as PMT7, using S-adenosylmethionine (AdoMet) as the methyl donor. Arginine methylation is implicated in signal transduction, RNA transport, and RNA splicing (Miranda et al., 2004 [PubMed 15044439]). |
| UniProt Protein Function: | PRMT7: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo. Belongs to the protein arginine N-methyltransferase family. PRMT7 subfamily. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 2.1.1.125; EC 2.1.1.126; Methyltransferase; Methyltransferase, protein arginine; RNA processing Chromosomal Location of Human Ortholog: 16q22.1 Cellular Component: cytosol; fibrillar center; nucleoplasm; nucleus Molecular Function:[myelin basic protein]-arginine N-methyltransferase activity; histone binding; histone-arginine N-methyltransferase activity; protein-arginine N-methyltransferase activity; protein-arginine omega-N monomethyltransferase activity; protein-arginine omega-N symmetric methyltransferase activity; ribonucleoprotein binding; S-adenosylmethionine-dependent methyltransferase activity Biological Process: DNA methylation during gametogenesis; genetic imprinting; histone methylation; peptidyl-arginine methylation; regulation of protein binding; spliceosomal snRNP biogenesis Disease: Short Stature, Brachydactyly, Intellectual Developmental Disability, And Seizures |
| NCBI Summary: | This gene encodes a member of the protein arginine N-methyltransferase family of proteins. The encoded enzyme transfers single methyl groups to arginine residues to generate monomethylarginines on histone proteins as well as other protein substrates. This enzyme plays a role in a wide range of biological processes, including neuronal differentiation, male germ line imprinting, small nuclear ribonucleoprotein biogenesis, and regulation of the Wnt signaling pathway. Mutations in this gene underlie multiple related syndromes in human patients characterized by intellectual disability, short stature and other features. The encoded protein may promote breast cancer cell invasion and metastasis in human patients. [provided by RefSeq, May 2017] |
| UniProt Code: | Q9NVM4 |
| NCBI GenInfo Identifier: | 20137529 |
| NCBI Gene ID: | 54496 |
| NCBI Accession: | Q9NVM4.1 |
| UniProt Secondary Accession: | Q9NVM4,Q96PV5, Q9H9L0, B3KPR0, B3KUG9, B4E379, |
| UniProt Related Accession: | Q9NVM4 |
| Molecular Weight: | 78kDa |
| NCBI Full Name: | Protein arginine N-methyltransferase 7 |
| NCBI Synonym Full Names: | protein arginine methyltransferase 7 |
| NCBI Official Symbol: | PRMT7Â Â |
| NCBI Official Synonym Symbols: | SBIDDSÂ Â |
| NCBI Protein Information: | protein arginine N-methyltransferase 7 |
| UniProt Protein Name: | Protein arginine N-methyltransferase 7 |
| UniProt Synonym Protein Names: | Histone-arginine N-methyltransferase PRMT7; [Myelin basic protein]-arginine N-methyltransferase PRMT7 |
| UniProt Gene Name: | PRMT7Â Â |
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