Description
PROKR1 Antibody (PACO06765)
The PROKR1 Polyclonal Antibody (PACO06765) is a valuable tool for researchers studying PROKR1, a protein involved in various physiological processes, including angiogenesis, inflammation, and pain perception. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for Western blot applications. By binding to PROKR1, this antibody allows for the detection and analysis of the protein in different cell types, making it a versatile option for researchers in the fields of immunology, oncology, and neuroscience.
PROKR1, also known as G-protein coupled receptor 73 (GPR73), plays a crucial role in the regulation of diverse biological functions, including the development of blood vessels and the modulation of pain signaling pathways. Dysregulation of PROKR1 has been implicated in various diseases, such as cancer, inflammatory disorders, and neuropathic pain conditions. Studying the function of PROKR1 is essential for uncovering its potential as a therapeutic target in these pathological conditions and advancing the development of novel treatment strategies.
| Antibody Name: | PROKR1 Antibody (PACO06765) |
| Antibody SKU: | PACO06765 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | ELISA:1:20000, WB:1:500-1:2000, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from the N-terminal region of human PKR1. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot analysis of Jurkat cells using PKR1 Polyclonal Antibody. |
 | Western Blot analysis of COLO205 cells using PKR1 Polyclonal Antibody. |
| Synonyms: | PROKR1; GPR73; PKR1; Prokineticin receptor 1; PK-R1; G-protein coupled receptor 73; G-protein coupled receptor ZAQ; GPR73a |
| UniProt Protein Function: | PROKR1: Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1 Chromosomal Location of Human Ortholog: 2p13.1 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:G-protein coupled receptor activity; neuropeptide Y receptor activity Biological Process: cell surface receptor linked signal transduction; circadian rhythm; G-protein coupled receptor protein signaling pathway; negative regulation of apoptosis; neuropeptide signaling pathway |
| UniProt Code: | Q8TCW9 |
| NCBI GenInfo Identifier: | 33112428 |
| NCBI Gene ID: | 10887 |
| NCBI Accession: | Q8TCW9.1 |
| UniProt Secondary Accession: | Q8TCW9,Q53QT9, Q8NFJ7, A5JUU2, |
| UniProt Related Accession: | Q8TCW9 |
| Molecular Weight: | 44,770 Da |
| NCBI Full Name: | Prokineticin receptor 1 |
| NCBI Synonym Full Names: | prokineticin receptor 1 |
| NCBI Official Symbol: | PROKR1Â Â |
| NCBI Official Synonym Symbols: | ZAQ; PKR1; GPR73; GPR73a  |
| NCBI Protein Information: | prokineticin receptor 1 |
| UniProt Protein Name: | Prokineticin receptor 1 |
| UniProt Synonym Protein Names: | G-protein coupled receptor 73; G-protein coupled receptor ZAQ; GPR73a |
| Protein Family: | Prokineticin receptor |
| UniProt Gene Name: | PROKR1Â Â |
| UniProt Entry Name: | PKR1_HUMAN |
