The Protein AF-9 Polyclonal Antibody (CAB6798) is a high-quality antibody designed for research involving AF-9, a key protein involved in chromatin regulation and gene transcription. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it an ideal tool for studying AF-9 in various biological contexts.AF-9, also known as MLLT3, is a crucial component of the super elongation complex that regulates gene transcription and plays a role in cell differentiation and development. Dysregulation of AF-9 has been implicated in various cancers, including leukemia, making it a promising target for cancer research and therapy development.
The Protein AF-9 Polyclonal Antibody is validated for use in Western blot applications, enabling researchers to detect and analyze AF-9 expression in different cell types and tissues. By understanding the function and regulation of AF-9, researchers can gain insights into its role in disease processes and potentially uncover new therapeutic targets for cancer treatment.
Product Name:
MLLT3 Rabbit Polyclonal Antibody
SKU:
CAB6798
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human MLLT3/AF9 (NP_004520.2).
Enables chromatin binding activity and lysine-acetylated histone binding activity. Involved in several processes, including hematopoietic stem cell differentiation; positive regulation of transcription, DNA-templated; and regulation of stem cell division. Acts upstream of or within negative regulation of canonical Wnt signaling pathway and positive regulation of Wnt signaling pathway, planar cell polarity pathway. Located in cytosol and nucleoplasm. Part of transcription elongation factor complex.
Purification Method:
Affinity purification
Gene ID:
4300
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MLLT3/AF9 antibody (CAB6798) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
