Description
PTAFR Antibody (PACO29248)
The PTAFR Polyclonal Antibody (PACO29248) is a valuable tool for researchers studying the PTAFR protein, which plays a key role in inflammation and immune responses. This antibody, raised in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By binding to the PTAFR protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for studies in immunology, inflammation, and related fields.PTAFR, or Platelet-activating factor receptor, is involved in mediating inflammatory responses in the body and is known to be a crucial player in various diseases, including asthma, cardiovascular diseases, and neurodegenerative disorders.
By studying the function of PTAFR, researchers can gain valuable insights into the underlying mechanisms of these conditions and potentially uncover new therapeutic targets for treatment.Overall, the PTAFR Polyclonal Antibody (PACO29248) is a powerful tool for investigating the role of PTAFR in immune responses and inflammatory processes, paving the way for advancements in the understanding and treatment of a wide range of diseases.
| Antibody Name: | PTAFR Antibody (PACO29248) |
| Antibody SKU: | PACO29248 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Platelet-activating factor receptor protein (297-342AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: PTAFR antibody at 4µg/ml + Mouse lung tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 40 kDa Observed band size: 40 kDa . |
 | Immunofluorescent analysis of A431 cells using PACO29248 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO29248 at dilution of 1:100. |
| Background: | Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system. |
| Synonyms: | Platelet-activating factor receptor (PAF-R) (PAFr), PTAFR, PAFR |
| UniProt Protein Function: | PTAFR: Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth- muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol- calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.Protein type: Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCRChromosomal Location of Human Ortholog: 1p35-p34.3Cellular Component: nucleoplasm; membrane; intracellular membrane-bound organelle; integral to plasma membrane; integral to membrane; plasma membraneMolecular Function: G-protein coupled receptor activity; platelet activating factor receptor activity; purinergic nucleotide receptor activity, G-protein coupled; lipopolysaccharide binding; phospholipid binding; lipopolysaccharide receptor activityBiological Process: G-protein coupled receptor protein signaling pathway; phosphoinositide-mediated signaling; inositol trisphosphate biosynthetic process; cytokine and chemokine mediated signaling pathway; lipopolysaccharide-mediated signaling pathway; cytokine production; immune response; inflammatory response; chemotaxis |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011] |
| UniProt Code: | P25105 |
| NCBI GenInfo Identifier: | 257900493 |
| NCBI Gene ID: | 5724 |
| NCBI Accession: | NP_001158195.1 |
| UniProt Secondary Accession: | P25105,A3KMC8, A8K2H5 |
| UniProt Related Accession: | P25105 |
| Molecular Weight: | 39,203 Da |
| NCBI Full Name: | platelet-activating factor receptor |
| NCBI Synonym Full Names: | platelet-activating factor receptor |
| NCBI Official Symbol: | PTAFRÂ Â |
| NCBI Official Synonym Symbols: | PAFRÂ Â |
| NCBI Protein Information: | platelet-activating factor receptor; PAF-R |
| UniProt Protein Name: | Platelet-activating factor receptor |
| UniProt Synonym Protein Names: | |
| Protein Family: | |
| UniProt Gene Name: | PTAFRÂ Â |
| UniProt Entry Name: | PTAFR_HUMAN |
| Antibodies |
| PTAFR Antibody (PACO04803) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
