The PTPRG Antibody (CAB14253) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, has high reactivity with human samples and is suitable for use in Western blot applications. It specifically binds to the PTPRG protein, allowing for precise detection and analysis in various cell types.PTPRG is known for its role in modulating cell growth, differentiation, and adhesion through dephosphorylation of target proteins. Dysregulation of PTPRG has been implicated in various diseases, including cancer and neurological disorders.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
PTPRG Antibody
SKU:
CAB14253
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
PTPG, HPTPG, RPTPG, R-PTP-GAMMA, PTPRG
Positive Sample:
A-549, 293T, Mouse kidney, Mouse heart, Mouse liver, Rat spleen
Cellular Localization:
Membrane, Single-Pass Type I Membrane Protein.
Calculated MW:
162kDa
Observed MW:
140-162kDa
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene.
Purification Method
Affinity purification
Gene ID
5793
RRID
AB_2761114
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PTPRG Rabbit pAb (CAB14253) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s.
