The PTPRM Polyclonal Antibody (PAC018857) is specifically designed for research involving the PTPRM protein, a member of the protein tyrosine phosphatase (PTP) family. This antibody, generated in rabbits, is highly reactive with human samples and is validated for use in a variety of applications, including Western blot, immunohistochemistry, and immunofluorescence.PTPRM, also known as protein tyrosine phosphatase sigma, plays a crucial role in cell signaling and regulation, particularly in processes such as cell adhesion, migration, and growth. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, and autoimmune conditions. Therefore, studying the function and expression of PTPRM is essential for uncovering its role in disease pathogenesis and potential therapeutic interventions.
With its high specificity and sensitivity, the PTPRM Polyclonal Antibody (PAC018857) provides researchers with a valuable tool for investigating the biological function of PTPRM in different cell types and tissues. This antibody enables the detection and analysis of PTPRM protein levels, allowing for a deeper understanding of its involvement in physiological and pathological processes. Whether studying cancer biology, neuroscience, or immunology, this antibody is an indispensable resource for advancing research in diverse fields.
Antibody Name:
PTPRM Antibody (PACO18857)
Antibody SKU:
PACO18857
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human PTPRM
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO18857(PTPRM Antibody) at dilution 1/80, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO18857(PTPRM Antibody) at dilution 1/80, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms.
Synonyms:
Protein tyrosine phosphatase, receptor type, M
UniProt Protein Function:
PTPRM: a single-pass type I membrane protein involved in cell-cell adhesion through homophilic interactions. A protein-tyrosine phosphatase receptor of the class 2B subfamily. A negative regulator of proliferation and invasion of breast cancer cells. The PTPRM gene is frequently hypermethylated in sporadic cancers. Modulates p120 catenin phosphorylation, promoting adipogenic differentiation. Two isoforms of the human protein have been reported.Protein type: Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine; Membrane protein, integral; Phosphatase; EC 3.1.3.48Chromosomal Location of Human Ortholog: 18p11.2Cellular Component: cell-cell adherens junction; integral to plasma membrane; lamellipodium; perinuclear region of cytoplasm; cytoplasm; intercellular junctionMolecular Function: identical protein binding; protein binding; cadherin binding; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activityBiological Process: response to drug; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; homophilic cell adhesion; protein amino acid dephosphorylation; positive regulation of vasodilation; signal transduction; neurite development; retinal ganglion cell axon guidance
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008]
