The R3HCC1L Antibody (PACO19704) is a highly specific and sensitive tool for researchers studying the R3H domain and coiled-coil domain-containing protein 1-like (R3HCC1L). This antibody, derived from rabbits, is optimized for detection in human samples and has been validated for use in Western blot applications. By binding to the R3HCC1L protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for experiments in molecular biology and protein research.R3HCC1L is a lesser-known protein that has been implicated in various cellular processes, including RNA binding and gene expression regulation.
Its potential role in cell signaling and disease development makes it an intriguing target for studies in cancer biology, developmental biology, and epigenetics. By utilizing the R3HCC1L Antibody, researchers can gain valuable insights into the function and behavior of this protein, leading to a better understanding of its impact on cellular pathways and disease progression.
Antibody Name:
R3HCC1L Antibody (PACO19704)
Antibody SKU:
PACO19704
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human R3HCC1L
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO19704(R3HCC1L Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19704(R3HCC1L Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
C10orf28 (chromosome 10 open reading frame 28), also known as GIDRP88 (growth inhibition and differentiation-related protein 88) or putative mitochondrial space protein 32.1, is a 792 amino acid, protein that exists as three alternatively spliced isoforms. The gene encoding C10orf28 maps to human chromosome 10, which spans nearly 135 million base pairs, makes up approximately 4.5% of total DNA in cells and encodes nearly 1,200 genes. Several protein-coding genes, including those that encode for chemokines, cadherins, excision repair proteins, early growth response factors (Egrs) and fibroblast growth receptors (FGFRs), are located on chromosome 10. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, WolmanÂ’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.
Synonyms:
R3H domain and coiled-coil containing 1-like
UniProt Protein Function:
This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
