The Rab11-FIP2 Polyclonal Antibody (PAC022537) is a valuable tool for researchers studying Rab11-FIP2, a protein involved in intracellular membrane trafficking and recycling processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blotting.Rab11-FIP2 plays a crucial role in regulating endocytic recycling pathways, which are essential for maintaining cell homeostasis and proper functioning. By targeting the Rab11-FIP2 protein, this antibody allows for the detection and analysis of Rab11-FIP2 expression in different cell types, making it ideal for studies in cell biology and membrane trafficking research.
With its ability to specifically bind to Rab11-FIP2, this antibody is a valuable tool for investigating the function and localization of Rab11-FIP2 in various cellular processes. Understanding the role of Rab11-FIP2 is essential for unraveling the complexities of intracellular trafficking and its implications in diseases such as cancer, neurodegenerative disorders, and infectious diseases. Researchers can utilize this antibody to further explore the mechanisms underlying these pathological conditions and develop targeted therapies for potential clinical applications.
Antibody Name:
RAB11FIP2 Antibody (PACO22537)
Antibody SKU:
PACO22537
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from internal of human RAB11FIP2.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from A549 cells, COLO cells, HUVEC cells and MCF-7 cells, using RAB11FIP2 antibody.
Background:
A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity.
Synonyms:
KIAA0941; NRip11; Rab11 family-interacting protein 2; Rab11-FIP2; RFIP2
UniProt Protein Function:
A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity.
