The Rab11FIP3 Polyclonal Antibody (PACO05806) is a valuable tool for researchers studying Rab11FIP3, a key regulator of intracellular membrane trafficking. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blotting. By specifically binding to Rab11FIP3, this antibody enables precise detection and analysis of the protein in different cell types, making it an excellent choice for investigations in cell biology and molecular biology.Rab11FIP3, also known as Rab11 family-interacting protein 3, plays a crucial role in coordinating vesicle transport and membrane recycling processes within cells. Its involvement in intracellular trafficking pathways makes it a promising target for research on cellular signaling, organelle dynamics, and disease mechanisms.
By studying Rab11FIP3, researchers can gain insights into various cellular processes and potentially uncover new therapeutic strategies for conditions related to membrane trafficking dysregulation.Overall, the Rab11FIP3 Polyclonal Antibody (PACO05806) offers a reliable and specific tool for elucidating the functions of Rab11FIP3 in cellular physiology and pathology. Its use in experimental settings can contribute to advancing our understanding of intracellular membrane dynamics and uncovering novel molecular targets for future drug development efforts.
Antibody Name:
RAB11FIP3 Antibody (PACO05806)
Antibody SKU:
PACO05806
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:10000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthesized peptide derived from the C-terminal region of human Rab11-FIP3.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
RAB11FIP3; ARFO1; KIAA0665; Rab11 family-interacting protein 3; FIP3-Rab11; Rab11-FIP3; Arfophilin-1; EF hands-containing Rab-interacting protein; Eferin; MU-MB-17.148
UniProt Protein Function:
RAB11FIP3: Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton. 3 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 16p13.3Cellular Component: nucleoplasm; centrosome; recycling endosome; intercellular bridge; intracellular membrane-bound organelle; recycling endosome membrane; microtubule organizing center; midbody; cytosol; endosome; cleavage furrowMolecular Function: ADP-ribosylation factor binding; protein binding; protein homodimerization activity; calcium ion binding; Rab GTPase bindingBiological Process: vesicle-mediated transport; organelle organization and biogenesis; cytokinesis; endocytic recycling
UniProt Protein Details:
NCBI Summary:
Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP3 is one of many proteins that interact with and regulate Rab GTPases (Hales et al., 2001 [PubMed 11495908]).[supplied by OMIM, Mar 2008]
