The Rab3C Polyclonal Antibody (PAC017551) is a valuable tool for researchers studying Rab3C, a protein involved in regulating vesicle trafficking and exocytosis in cells. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blotting applications. By binding to the Rab3C protein, this antibody enables precise detection and analysis of Rab3C levels in a variety of cell types, making it ideal for investigations in cell biology and neuroscience.Rab3C is a member of the Rab family of small GTPases, which play essential roles in intracellular membrane trafficking. Specifically, Rab3C is implicated in the regulation of synaptic vesicle exocytosis and neurotransmitter release, making it a key player in neuronal communication and synaptic function.
Research into Rab3C function is crucial for understanding the mechanisms underlying synaptic transmission and potential implications for neurological disorders.By utilizing the Rab3C Polyclonal Antibody, researchers can explore the role of Rab3C in various cellular processes and gain insights into its potential involvement in neurological diseases such as Alzheimer's and Parkinson's. This antibody offers a reliable tool for investigating the function of Rab3C and its impact on vesicle trafficking and neurotransmission, providing valuable information for advancing our understanding of cellular communication in health and disease.
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human fetal brain tissue, 293T cells, Primary antibody: PACO17551(RAB3c Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute.
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO17551(RAB3c Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Ras-related protein Rab-3C is a protein that in humans is encoded by the RAB3C gene.RAB proteins, such as RAB3C, are small GTPases implicated in the regulation of vesicular trafficking between membrane compartments.It involved in rotein transport and vesicular traffic probably.
Synonyms:
Ras-related protein Rab-3C
UniProt Protein Function:
RAB3C: Protein transport. Probably involved in vesicular traffic. Belongs to the small GTPase superfamily. Rab family.
UniProt Protein Details:
Protein type:G protein; G protein, monomeric, Rab; G protein, monomeric
Chromosomal Location of Human Ortholog: 5q13
Cellular Component: synaptic vesicle; secretory granule membrane; perinuclear region of cytoplasm; plasma membrane; cytosol; vesicle; endosome
Molecular Function:GTPase activity; protein binding; GDP binding; GTP binding; myosin V binding
Biological Process: regulation of exocytosis; intracellular protein transport; antigen processing and presentation; synaptic vesicle exocytosis; metabolic process; protein secretion; Rab protein signal transduction; vesicle docking during exocytosis
NCBI Summary:
This gene is a member of the RAS oncogene family and encodes a small GTPase. Other similar small GTPases are known to be involved in vesicle trafficking, and the encoded protein was shown to play a role in recycling phagocytosed MHC class 1 complexes to the cell surface. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
