The RABGEF1 Polyclonal Antibody (PAC011680) is a versatile tool for researchers studying RABGEF1, a protein involved in intracellular membrane trafficking and signal transduction processes. This antibody, generated in rabbits, exhibits strong reactivity with human samples and has been specifically validated for use in Western blot applications.RABGEF1 plays a crucial role in regulating the activity of Rab proteins, which are key regulators of vesicle trafficking within cells. Dysregulation of RABGEF1 has been linked to various diseases, including cancer and neurodegenerative disorders.
By targeting RABGEF1 with this antibody, researchers can investigate its expression levels and functional roles in different cell types and disease contexts.With its high specificity and sensitivity, the RABGEF1 Polyclonal Antibody is an essential tool for studies in cell biology, cancer research, and neurobiology. By enabling the detection and analysis of RABGEF1 protein, this antibody opens up new possibilities for understanding the molecular mechanisms underlying cellular processes and disease pathogenesis.
RABGEF1: Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase. Interacts with RGS14; the interaction is GTP-dependent. Heterodimer with RABEP1. The heterodimer binds RAB4A and RAB5A that have been activated by GTP-binding. Interacts with RAB21, and with 100-fold lower affinity also with RAB22. Binds TSC2, GGA1, GGA2, GGA3, AP1G1 and AP1G2. Interacts with ubiquitinated EGFR. 3 isoforms of the human protein are produced by alternative splicing.Protein type: GAP, Rab; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 7q11.21Cellular Component: early endosomeMolecular Function: protein binding; Rab GTPase binding; Rab guanyl-nucleotide exchange factor activityBiological Process: protein targeting to membrane
UniProt Protein Details:
NCBI Summary:
RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A; MIM 179512) (Horiuchi et al., 1997 [PubMed 9323142]).[supplied by OMIM, Mar 2010]
