The RAI1 Polyclonal Antibody (PAC052486) is a valuable tool for researchers studying RAI1, a transcription factor involved in multiple cellular processes, including cell growth and development. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for use in Western blot and immunohistochemistry applications.RAI1, also known as Retinoic Acid-Induced protein 1, is particularly important in the regulation of gene expression and cellular functions. Dysregulation of RAI1 has been linked to developmental disorders and neurodevelopmental conditions such as Smith-Magenis syndrome.
By targeting RAI1 with this antibody, researchers can gain insights into its functions and potential implications in various diseases.With its ability to detect RAI1 protein in different cell types, the RAI1 Polyclonal Antibody is a valuable tool for investigating the molecular mechanisms underlying RAI1-related disorders. Its application in research focusing on gene expression and developmental biology makes it a versatile asset for scientists exploring the intricate workings of cellular processes.
Western Blot. Positive WB detected in: HepG2 whole cell lysate. All lanes: RAI1 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 204, 199, 176, 105 kDa. Observed band size: 204 kDa.
Immunohistochemistry of paraffin-embedded human ovarian cancer using PACO52486 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human heart tissue using PACO52486 at dilution of 1:100.
Background:
Transcriptional regulator of the circadian clock components: CLOCK, ARNTL/BMAL1, ARNTL2/BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation.
