The RANBP17 Antibody (PAC061189) is a highly specific and reliable tool for research involving Ran Binding Protein 17 (RANBP17), a protein involved in nucleocytoplasmic transport and mitotic spindle assembly. This antibody, generated in rabbits, is optimized for use in immunohistochemistry and immunofluorescence applications, allowing for the visualization and localization of RANBP17 in various cell types.RANBP17 is essential for the proper functioning of cellular processes such as nuclear transport and cell division, making it a key player in cell biology and developmental processes.
Dysfunction of RANBP17 has been linked to disorders such as cancer and neurodegenerative diseases, highlighting its importance as a potential therapeutic target.By using the RANBP17 Antibody, researchers can gain valuable insights into the function and localization of RANBP17 in normal and diseased cells, providing a deeper understanding of its role in cellular processes. This antibody is a valuable tool for studies in cell biology, oncology, and neurobiology, offering researchers the ability to investigate the intricate mechanisms underlying these complex biological processes.
IHC image of PACO61189 diluted at 1:100 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Western Blot. Positive WB detected in: A549 whole cell lysate. All lanes: RANBP17 antibody at 3.9µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 125, 66 kDa. Observed band size: 125 kDa.
Background:
May function as a nuclear transport receptor.
Synonyms:
Ran-binding protein 17, RANBP17
UniProt Protein Function:
RANBP17: May function as a nuclear transport receptor. Belongs to the exportin family.Protein type: Nuclear export; Nuclear importChromosomal Location of Human Ortholog: 5q34Cellular Component: cytoplasm; nuclear poreMolecular Function: nuclear export signal receptor activity; Ran GTPase bindingBiological Process: protein export from nucleus
UniProt Protein Details:
NCBI Summary:
The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]
