The RARRES1 Polyclonal Antibody (PAC018984) is a valuable tool for research involving the RARRES1 protein, which is known for its role in regulating cell proliferation and differentiation. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to RARRES1, it enables accurate detection and analysis in a variety of cell types, making it an excellent choice for studies in cancer biology and cell signaling pathways.
RARRES1, also known as retinoic acid receptor responder protein 1, is a key player in cellular processes such as apoptosis and cell cycle regulation. Its involvement in regulating tumor growth and metastasis underscores its importance in cancer research, with potential implications for developing targeted therapies. By studying the function of RARRES1, researchers can gain insights into its impact on cancer progression and potentially identify new therapeutic targets for cancer treatment.
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO18984(RARRES1 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 10+15%SDS-PAGE, Lysate: 50 μg, Lane: Human liver cancer tissue, Primary antibody: PACO18984(RARRES1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO18984(RARRES1 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene was identified as a retinoid acid, (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid, receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed.
RARRES1: identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 3q25.32
UniProt Protein Details:
NCBI Summary:
This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
