The RARRES1 Polyclonal Antibody (PAC018985) is a powerful tool for researchers studying RARRES1, a protein known for its role in cell differentiation and tumor suppression. This antibody, generated in rabbits, has high specificity for human samples and is validated for use in Western blot applications. By binding to the RARRES1 protein, this antibody enables researchers to accurately detect and analyze RARRES1 expression in various cell types, making it a valuable tool for studies in cancer biology and cell signaling.
RARRES1, also known as Retinoic Acid Receptor Responder Protein 1, is involved in the regulation of cell growth, differentiation, and apoptosis. Its tumor-suppressing properties make it a potential target for cancer therapy, as dysregulation of RARRES1 has been implicated in various types of cancer. By studying the function and expression of RARRES1, researchers can gain valuable insights into the mechanisms of cancer development and potentially identify new therapeutic targets for treatment.
Antibody Name:
RARRES1 Antibody (PACO18985)
Antibody SKU:
PACO18985
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:5000-1:20000, IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human RARRES1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO18985(RARRES1 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO18985(RARRES1 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene was identified as a retinoid acid, (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid, receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed.
RARRES1: identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 3q25.32
UniProt Protein Details:
NCBI Summary:
This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
