Description
RASA3 Antibody (PACO00836)
The RASA3 Polyclonal Antibody (PACO00836) is a valuable tool for researchers studying RASA3, a protein involved in cell signaling pathways and immune response regulation. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the RASA3 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in immunology and cancer research.RASA3, also known as Ras GTPase-activating protein 3, plays a crucial role in controlling the activity of Ras proteins, key regulators of cell growth and differentiation.
Dysregulation of Ras signaling pathways has been linked to various diseases, including cancer and developmental disorders. By studying the function of RASA3, researchers can gain insights into the mechanisms underlying these conditions and potentially identify novel therapeutic targets.Overall, the RASA3 Polyclonal Antibody is a valuable tool for advancing our understanding of signaling pathways involved in immune regulation and disease development. Its high specificity and reliability make it an essential component of any research project focused on RASA3 and its role in health and disease.
| Antibody Name: | RASA3 Antibody |
| Antibody SKU: | PACO00836 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | WB:1:500-1:2000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the Internal region of human GAP1-InsP4 BP. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | RASA3; Ras GTPase-activating protein 3; GAP1(IP4BP); Ins P4-binding protein |
| UniProt Protein Function: | RASA3: Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor. |
| UniProt Protein Details: | Protein type:GAPs; GAPs, Ras Chromosomal Location of Human Ortholog: 13q34 Cellular Component: cytoplasm; cytosol Molecular Function:calcium-release channel activity Biological Process: MAPKKK cascade; negative regulation of Ras protein signal transduction; signal transduction |
| NCBI Summary: | This gene encodes a protein that binds inositol 1,3,4,5-tetrakisphosphate and stimulates the GTPase activity of Ras p21. This protein functions as a negative regulator of the Ras signalling pathway. It is localized to the cell membrane via a pleckstrin homology (PH) domain in the C-terminal region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] |
| UniProt Code: | Q14644 |
| NCBI GenInfo Identifier: | 206729910 |
| NCBI Gene ID: | 22821 |
| NCBI Accession: | Q14644.3 |
| UniProt Secondary Accession: | Q14644,Q8IUY2, A6NL15, F8W6X8, |
| UniProt Related Accession: | Q14644 |
| Molecular Weight: | 92,228 Da |
| NCBI Full Name: | Ras GTPase-activating protein 3 |
| NCBI Synonym Full Names: | RAS p21 protein activator 3 |
| NCBI Official Symbol: | RASA3Â Â |
| NCBI Official Synonym Symbols: | GAPIII; GAP1IP4BPÂ Â |
| NCBI Protein Information: | ras GTPase-activating protein 3 |
| UniProt Protein Name: | Ras GTPase-activating protein 3 |
| UniProt Synonym Protein Names: | GAP1(IP4BP); Ins P4-binding protein |
| Protein Family: | Ras GTPase-activating protein |
| UniProt Gene Name: | RASA3Â Â |
| UniProt Entry Name: | RASA3_HUMAN |
