Description
system_update_altDatasheet
| Product Name: | Rat CD43 monoclonal antibody (FITC) |
| Product Code: | AGIM0281 |
| Size: | 500 µL |
| Reactivity: | Rat |
| Clone: | W3/13 |
| Applications: | Flow Cytometry |
| Conjugate: | FITC |
| Isotype: | IgG1 |
| Host Species: | Mouse |
| Storage: | Store at 4°C. Avoid prolonged exposure to light. |
| Uniprot: | P13838 |
| UniProt Protein Function: | sialophorin: One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1. During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response (By similarity) Protein type: Cell surface; Membrane protein, integral Cellular Component: basement membrane; cell surface; cleavage furrow; external side of plasma membrane; extracellular space; integral to plasma membrane; membrane; microvillus; uropod Molecular Function: protein domain specific binding Biological Process: cell surface receptor linked signal transduction; chronic inflammatory response; defense response to bacterium; monocyte activation; negative regulation of cell adhesion; negative regulation of T cell activation; negative regulation of T cell proliferation; negative regulation of type IV hypersensitivity; negative thymic T cell selection; positive regulation of protein amino acid phosphorylation; positive regulation of T cell proliferation; positive regulation of tumor necrosis factor biosynthetic process; regulation of defense response to virus; regulation of immune response; response to protozoan; T cell costimulation |
| UniProt Protein Details: | |
| NCBI Summary: | major glycoprotein of thymocytes and T lymphocytes [RGD, Feb 2006] |
| UniProt Code: | P13838 |
| NCBI GenInfo Identifier: | 126215 |
| NCBI Gene ID: | 24796 |
| NCBI Accession: | P13838.1 |
| UniProt Secondary Accession: | P13838 |
| UniProt Related Accession: | P13838 |
| Molecular Weight: | 38,426 Da |
| NCBI Full Name: | Leukosialin |
| NCBI Synonym Full Names: | sialophorin |
| NCBI Official Symbol: | Spn  |
| NCBI Official Synonym Symbols: | Lsn; Cd43; Lsn1; gpL115Â Â |
| NCBI Protein Information: | leukosialin |
| UniProt Protein Name: | Leukosialin |
| UniProt Synonym Protein Names: | Leukocyte sialoglycoprotein; Sialophorin; W3/13 antigen; CD_antigen: CD43 |
| Protein Family: | Leukosialin |
| UniProt Gene Name: | Spn  |
| UniProt Entry Name: | LEUK_RAT |
