RB Rabbit Polyclonal Antibody (CAB17005)
- SKU:
- CAB17005
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
Product Name: | RB Rabbit Polyclonal Antibody |
SKU: | CAB17005 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 701-928 of human RB (NP_000312.2). |
Sequence: | DQIM MCSM YGIC KVKN IDLK FKII VTAY KDLP HAVQ ETFK RVLI KEEE YDSI IVFY NSVF MQRL KTNI LQYA STRP PTLS PIPH IPRS PYKF PSSP LRIP GGNI YISP LKSP YKIS EGLP TPTK MTPR SRIL VSIG ESFG TSEK FQKI NQMV CNSD RVLK RSAE GSNP PKPL KKLR FDIE GSDE ADGS KHLP GESK FQQK LAEM TSTR TRMQ KQKM NDSM DTSN KEEK |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:100 IF/ICC,1:50 - 1:100 |
Synonyms: | RB; pRb; OSRC; pp110; p105-Rb; PPP1R130; p110-RB1 |
Positive Sample: | Y79,Mouse thymus,Rat kidney |
Cellular Localization: | Nucleus. |
Calculated MW: | 106kDa |
Observed MW: | 110kDa |
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
Purification Method: | Affinity purification |
Gene ID: | 5925 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |