The RBM38 Polyclonal Antibody (PAC020325) is a valuable tool for researchers studying RBM38, a key RNA-binding protein involved in post-transcriptional gene regulation. This antibody, raised in rabbits, is highly specific to human RBM38 and has been validated for use in Western blot applications. By binding to RBM38 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for investigations in RNA biology and cancer research.RBM38, also known as RBD1, plays a crucial role in regulating mRNA stability and translation, impacting gene expression and cellular processes.
Dysregulation of RBM38 has been linked to cancer development and progression, making it a promising target for therapeutic intervention. Research into the functions of RBM38 is essential for uncovering its potential role in disease pathogenesis and identifying novel treatment strategies.Overall, the RBM38 Polyclonal Antibody is a reliable tool for investigating the function of RBM38 in various biological contexts, providing valuable insights into gene regulation mechanisms and offering potential opportunities for therapeutic targeting in cancer and other diseases.
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20325(RBM38 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 40 µg, Lane: Human heart tissue, Primary antibody: PACO20325(RBM38 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20325(RBM38 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
RBM38 (RNA-binding protein 38), also known as RNPC1 or SEB4. RBM38 is a cell cycle protein found in the cytosol and the Nucleus that exists as two alternatively spliced isoforms, 1 (RNPC1a) and 2 (RNPC1b), of 239 and 121 amino acid, , respectively. Independent of p53 expression, RBM38 isoform 1 induces cell cycle arrest in G1 phase through maintaining transcript stability at the 3Â’-UTR of p21, a regulator of cell cycle progression at S phase. RBM38 is also an mRNA splicing factor that regulates the expression of FGFR2. RBM38 contains one RRM (RNA recognition motif) domain.
Synonyms:
RNA binding motif protein 38
UniProt Protein Function:
CDH4: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development. Expressed mainly in brain but also found in other tissues.Protein type: Motility/polarity/chemotaxis; Cell adhesion; Membrane protein, integralChromosomal Location of Human Ortholog: 20q13.3Cellular Component: integral to plasma membrane; plasma membraneMolecular Function: calcium ion bindingBiological Process: heterophilic cell adhesion; axon guidance; intercellular junction assembly and maintenance; positive regulation of axon extension; cell adhesion; homophilic cell adhesion
