The RBM38 Polyclonal Antibody (PACO20326) is a valuable tool for researchers studying RNA-binding motif protein 38 (RBM38), a key player in post-transcriptional gene regulation. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards RBM38 in human samples, making it ideal for Western blotting applications.RBM38 is known to interact with various RNA molecules, influencing their stability and translation. Its role in regulating gene expression makes it a promising target for research in fields such as RNA biology, cancer biology, and developmental biology.
By detecting and analyzing RBM38 expression levels in different cell types, this antibody provides valuable insights into the molecular mechanisms underlying these processes.Furthermore, understanding the functions of RBM38 can offer potential therapeutic strategies for diseases associated with dysregulated gene expression, including cancer and neurological disorders. With the use of the RBM38 Polyclonal Antibody, researchers can advance their studies in RNA biology and contribute to the development of novel treatments targeting RBM38-mediated pathways.
Antibody Name:
RBM38 Antibody (PACO20326)
Antibody SKU:
PACO20326
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:50-1:300
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human RBM38
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20326(RBM38 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20326(RBM38 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
RBM38 is a cell cycle protein found in the cytosol and the nucleus that exists as two alternatively spliced isoforms, 1 (RNPC1a) and 2 (RNPC1b), of 239 and 121 amino acid, , respectively. Independent of p53 expression, RBM38 isoform 1 induces cell cycle arrest in G1 phase through maintaining transcript stability at the 3Â’-UTR of p21, a regulator of cell cycle progression at S phase. RBM38 is also an mRNA splicing factor that regulates the expression of FGFR2. RBM38 contains one RRM (RNA recognition motif) domain.
Synonyms:
RNA binding motif protein 38
UniProt Protein Function:
CDH4: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development. Expressed mainly in brain but also found in other tissues.Protein type: Motility/polarity/chemotaxis; Cell adhesion; Membrane protein, integralChromosomal Location of Human Ortholog: 20q13.3Cellular Component: integral to plasma membrane; plasma membraneMolecular Function: calcium ion bindingBiological Process: heterophilic cell adhesion; axon guidance; intercellular junction assembly and maintenance; positive regulation of axon extension; cell adhesion; homophilic cell adhesion
