ASGR1 is a subunit of the asialoglycoprotein receptor. ASGR1 is a transmembrane protein that controls endocytosis and lysosomal breakdown of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues, which is critical for glycoprotein homeostasis. The asialoglycoprotein receptor serves as a target for liver-specific drug delivery, and it may aid viral infection in the liver by many pathogens, including hepatitis B. The asialoglycoprotein receptor is a heteropolymeric protein with two distinct genes encoding its major and minor components. Hepatitis is a condition that is associated with ASGR1. Protein metabolism and transport to the Golgi and subsequent modification are two examples of ASGR1 related pathways. Human ASGR1/ASGPR1 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Human ASGR1/ASGPR1 Recombinant Protein (RPES3554)
Product Code:
RPES3554
Size:
10µg
Species:
Human
Expressed Host:
Human Cells
Synonyms:
Asialoglycoprotein Receptor 1, ASGP-R 1, ASGPR 1, C-Type Lectin Domain Family 4 Member H1, Hepatic Lectin H1, HL-1, ASGR1, CLEC4H1
Accession:
P07306
Sequence:
Gln62-Ile291
Fusion tag:
C-6His
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human Asialoglycoprotein Receptor 1 is produced by our Mammalian expression system and the target gene encoding Gln62-Ile291 is expressed with a 6His tag at the C-terminus.
Purity:
> 90 % as determined by reducing SDS-PAGE.
Mol Mass:
27.4 kDa
AP Mol Mass:
38 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of 20mM PB; 150mM NaCl; pH 7.2.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
