CCL2 (Chemokine (C-C Motif) Ligand 2, also known as Monocyte Chemoattractant Protein (MCP-1) and Small Inducible Cytokine A2 (SCYA2)) is a small cytokine that belongs to the CC chemokine family and is involved in monocyte attraction. Its cognate receptor, CCR2, play a critical role in regulating nociceptive processes during neuropathic pain. CCL2 and CCR2 are both linked to the development of autoimmunity. CCL2 stimulates recruitment of monocytes, memory T cells, and dendritic cells to inflammatory sites caused by either tissue injury or infection. CCL2 has been found to play a role in fibrosis and is now being studied as a biomarker and therapeutic target. Human CCL2/MCP Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Human CCL2/MCP Recombinant Protein (RPES4803)
Product Code:
RPES4803
Size:
20 µg
Species:
Human
Expressed Host:
E.coli
Synonyms:
C-C motif chemokine 2, HC11, Monocyte chemoattractant protein 1, Monocyte chemotactic and activating factor, MCAF, Monocyte chemotactic protein 1, MCP-1, Monocyte secretory protein JE, Small-inducible cytokine A2, CCL2
Accession:
P13500
Sequence:
Gln24-Thr99
Fusion tag:
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human C-C Motif Chemokine 2 is produced by our E.coli expression system and the target gene encoding Gln24-Thr99 is expressed.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
8.7 kDa
AP Mol Mass:
13 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of 20mM PB, 150mM NaCl, pH7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
