CD300A is a single-pass type I membrane protein which belongs to the CD300 family. It contains 1 Ig-like V-type (immunoglobulin-like) domain. The CD300 family of myeloid immunoglobulin receptors includes activating (CD300b; CD300e) and inhibitory members (CD300a; CD300f); as well as molecules presenting a negative charge within their transmembrane domain (CD300c; CD300d). It is expressed not only by natural killer (NK) cells but also by T-cell subsets; B-cells; dendritic cells; mast cells; granulocytes and monocytes. CD300A is an inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells; and to the down-regulation of mast cell degranulation. CD300c is a functional immune receptor able to deliver activating signals upon ligation in RBL-2H3 mast cells.
Product Name:
Human CD300a/LMIR1 Recombinant Protein (RPES3485)
Product Code:
RPES3485
Size:
10µg
Species:
Human
Expressed Host:
Human Cells
Synonyms:
CMRF35-Like Molecule 8, CLM-8, CD300 Antigen-Like Family Member A, CMRF-35-H9, CMRF35-H9, CMRF35-H, IRC1/IRC2, Immunoglobulin Superfamily Member 12, IgSF12, Inhibitory Receptor Protein 60, IRp60, NK Inhibitory Receptor, CD300a, CD300A, CMRF35H, IGSF12
Accession:
Q9UGN4
Sequence:
Leu18-Gln178
Fusion tag:
C-Fc-6His
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human Leukocyte mono-Ig-like receptor 1 is produced by our Mammalian expression system and the target gene encoding Leu18-Gln178 is expressed with a Fc; 6His tag at the C-terminus.
Purity:
> 90 % as determined by reducing SDS-PAGE.
Mol Mass:
45.4 kDa
AP Mol Mass:
75 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of 20mM Tris;150mM NACl;5% Trehalose;pH 8.0.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
