Beta-defensin 1 (DEFB1) is a member of the beta-defensin family, which is widely expressed by epithelial cells. Beta-defensin are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal peptide. The six-cysteine motif of Beta-defensin forms three internal disulfide bonds. Beta-defensin 1 is an antimicrobial peptide that has been shown to have an in the resistance of epithelial surfaces to microbial colonization. Defects in the beta-defensin 1 play a role in the diagnosis of asthma and has gender-specific effects in humans. Beta-defensins 1 has been implicated in severe sepsis. In addition, gingival keratinocytes' induction profiles are linked to beta-defensin 1. Human Beta-Defensin 1/DEFB1 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Human Beta-Defensin 1/DEFB1 Recombinant Protein (RPES3487)
Recombinant Human beta-Defensin 1 is produced by our E.coli expression system and the target gene encoding Gly22-Lys68 is expressed.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
5.1 kDa
AP Mol Mass:
6 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of 20mM PB, 130mM NaCl, pH 7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
