Description
| Product Name: | Recombinant Human DKK-3 Protein (His Tag) |
| SKU: | RPES8360 |
| Size: | 20μg |
| Tag: | C-His |
| Reactivity: | Human |
| Expression Host: | Mammalian |
| Accession: | Q9UBP4 |
| Sequence: | Ala22-Ile350 |
| Calculated Molecular Weight: | 36.0 kDa |
| Observed Molecular Weight: | 50 kDa |
| Synonyms: | UNQ, PRO, Dickkopf-Related Protein, hDkk, Dickkopf, DKK, DKK3, REIC, RIG, Dickkopf-3, Dickkopf-Related Protein 3, Dkk-3, hDkk-3, UNQ258, PRO295, Dickkopf 3, Dickkopf 3 homolog, Dickkopf 3 homolog (Xenopus laevis), Dickkopf homolog 3, Dickkopf related protein 3, Dickkopf related protein 3 Precursor, Dickkopf WNT signaling pathway inhibitor 3, Dickkopf3, DKK 3, hDkk 3, hDkk3, homolog of, Regulated in glioma, RIG-like 5-6, RIG-like 7-1, Xenopus |
| Endotoxin: | < 1.0 EU/mg of the protein as determined by the LAL method |
| Purity: | > 90% as determined by reducing SDS-PAGE. |
DKK3 (dickkopf related protein 3) is a member of the dickkopf-related family consisting of DKK1 , DKK2 , DKK3 and DKK4. It is a secreted protein , and also known as REIC (Reduced Expansion in Immortalized Cells). The DKK3 protein is proposed to function as a secreted tumor suppressor since it is downregulated in a number of cancer cells and prostate cancer tissue and may be a promising candidate molecule for therapeutic interference. DKK3 protein is also a negative regulator of beta-catenin and its downregulation contribute to an activation of the beta-catenin signaling pathway.
| Bio-activity: | Not validated for activity |
| Formulation: | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution: | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Storage: | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
