Complement factor D; also known as adipsin; is a member of the chymotrypsin family of serine proteases; which plays an essential role in host defense as the rate-limiting enzyme in the alternative pathway of complement activation. Complement factor D activates a convertase (C3bBb) responsible for cleavage of the complement protein C3; which leads to the activation of terminal complement component C5-9 to form the membrane attack complex on microbial or cellular surfaces. It also functions in the regulation of systemic energy balance and physiologic and pathologic processes; including immunity and inflammation.
Recombinant Human Complement factor D is produced by our Mammalian expression system and the target gene encoding Ile26-Ala253 is expressed with a 10His tag at the C-terminus.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
25.8 kDa
AP Mol Mass:
28 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of 20mM Tris; 150mM NaCl; pH7.5.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
