FcRn complex consist of two subunits: IgG receptor FcRn large subunit p51?alpha chain) and Beta-2-microglobulin?Beta chain). The complexes is similar in structure to MHC class I-like heterodimer. Beta-2-microglobulin involved in the presentation of peptide antigens to the immune system. FcRn binds to the Fc region of monomeric immunoglobulins gamma, mediates the uptake of IgG from milk,Possible role in transfer of immunoglobulin G from mother to fetus. A principal component of antibody transport is the neonatal receptor for the Fc portion of immunoglobulin, a heterodimer of a MHC-1 alpha-chain homolog ( FcRn ) and beta-2-microglobulin ( B2M ).
Product Name:
Human FcRn & B2M Heterodimer Recombinant Protein (RPES3629)
Product Code:
RPES3629
Size:
10µg
Species:
Human
Expressed Host:
Human Cells
Synonyms:
IgG receptor FcRn,Neonatal Fc receptor,FCRN
Accession:
P55899&P61769
Sequence:
Ala24-Leu290&Ile21-Met 119
Fusion tag:
C-6His
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human IgG Fc fragment receptor transporter is produced by our Mammalian expression system and the target gene encoding Ala24-Leu290&Ile21-Met119 is expressed with a 6His tag at the C-terminus.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
41.4 kDa
AP Mol Mass:
13&37 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of 50mM HEPES,150mM Nacl,pH7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
