GLP1R is a 7-transmembrane protein that functions as a receptor for the glucagon-like peptide 1 (GLP-1) hormone. GLP-1 stimulates glucose-induced insulin secretion. This receptor, which is found on the cell surface and plays a role in insulin release signalling pathways in response to GLP-1 and GLP-1 analogues, is internalised. In animal studies, GLP1R has been linked to brain health due to it's function in neuroprotective. For type 2 diabetes and stroke treatment, the protein is a promising therapeutic target. Polymorphisms in the GLP1R gene are linked to diabetes, indicating that the protein is a promising drug target for type 2 diabetes treatment. Hyperglycemia and insulinoma are two diseases linked to the GLP1R. GLP1R has been linked with the presynaptic function and G alpha (s) signalling events of Kainate receptors. Human GLP1R Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Recombinant Human LP1R is produced by our Mammalian expression system and the target gene encoding Arg24-Tyr145 is expressed with a Fc tag at the C-terminus.
Purity:
> 90% as determined by reducing SDS-PAGE.
Mol Mass:
41.2 kDa
AP Mol Mass:
55-60 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
