X-linked interleukin-1 receptor accessory protein-like 2 (IL1RAPL2) or Interleukin-1 receptor 9 (IL-1R9) is a member of the interleukin 1 receptor family. This protein is similar to the interleukin 1 accessory proteins. IL-1R9/IL1RAPL2 shows restricted expression in fetal brain and is highly homologous to IL1RAPL; which is reportedly involved in nonsyndromic X-linked mental retardation. IL-1R9/IL1RAPL2 is highly homologous to IL-1R8. Both forms have no known ligands and receptor are found in the fetal brain. IL-1R9/IL1RAPL2 may function as a negative receptor. Both IL1RAPL1 and IL1RAPL2 have novel C-terminal sequences not present in other related proteins. IL-1R9/IL1RAPL2 may be strong candidates for X-linked non-syndromic mental retardation loci; and that molecules resembling IL-1 and IL-18 play a role in the development or function of the central nervous system.
Product Name:
Human ILR9/IL1RAPL2 Recombinant Protein (RPES1344)
Product Code:
RPES1344
Size:
100µg
Species:
Human
Expressed Host:
HEK293 Cells
Synonyms:
IL-1R9,IL1R9,IL1RAPL-2,TIGIRR-1
Accession:
NP_059112.1
Sequence:
Met 1-Glu 356
Fusion tag:
C-Fc
Activity:
Measured by its ability to bind biotinylated human IL1? in functional ELISA.
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the extracellular domain (Met 1-Glu 356) of human IL1R9 (NP_059112.1) precursor was expressed with the fused Fc region of human IgG1 at the C-terminus.
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
