ITPA belongs to the HAM1 NTPase protein family and functions as a homodimer in the cytoplasm. Defects in ITPA can lead to disorders such as inosine triphosphatase deficiency and epileptic encephalopathy by causing ITP to accumulate in red blood cells. Pharmacokinetics/pharmacodynamics, the thiopurine pathway, and purine metabolism are all ITPA-related pathways. Human ITPase/ITPA Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Recombinant Human Inosine Triphosphate Pyrophosphatase is produced by our E.coli expression system and the target gene encoding Ala2-Ala194 is expressed with a 6His tag at the C-terminus.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
22.5 kDa
AP Mol Mass:
21 kDa
Formulation:
Supplied as a 0.2 µm filtered solution of 20mM TrisHCl, pH 8.0.
Shipping:
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
Stability and Storage:
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
