Human KIR2DL3/NKAT2 Recombinant Protein (RPES2987)

SKU:
RPES2987
Product type:
Recombinant Protein
Host species:
Human Cells
Reactivity:
Human
$155

Description

ELISA Kit Technical Manual

Recombinant Human KIR2DL3/NKAT2 Protein (Fc Tag)

Background:Killer-Cell Immunoglobulin-Like Receptors (KIRs) are important cells of the immune system. KIRs are a family of Natural Killer (NK) Cells surface glycoproteins. KIRs control the killing function of these cells by interacting with MHC class I molecules. This interaction allows KIRs to identify virally infected cells or tumor cells by the distinctive low level of Class I MHC on their surface. The majority of KIRs are inhibitory, their recognition of MHC suppresses the cytotoxic activity of their NK cell. Only a limited number of KIRs have the capacity to activate cells. KIR2DL3 is an inhibitory Killer Cell Ig-like Receptor. KIR2DL3 recognizes class I MHC molecules (HLA-Cw1, -Cw3, -Cw7, and Cw8). KIR2DL3 inhibits the activity of NK cells thus preventing cell lysis.
Name:Recombinant Human KIR2DL3/NKAT2 Protein (Fc Tag)
Size:10µg
Assay Genie SKU:RPES2987
Synonyms:Killer cell immunoglobulin-like receptor 2DL3; KIR2DL3; CD158b2; NKAT2; CD158 antigen-like family member B2; KIR-023GB; Killer inhibitory receptor cl 2-3; MHC class I NK cell receptor; NKAT-2; p58 NK receptor CL-6
Species:Human
Expression host:Human Cells
Sequence:His22-His245
Accession:P43628
Mol Mass:51.7 kDa
AP Mol Mass:70-80 kDa
Tag:C-Fc
Purity:> 95 % as determined by reducing SDS-PAGE.
Endotoxin:< 1.0 EU per µg as determined by the LAL method.
Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8? for 2-7 days. Aliquots of reconstituted samples are stable at < -20'C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:Lyophilized from a 0.2 um filtered solution of PBS, pH7.4.
Reconstitution:Please refer to the printed manual for detailed information.
UniProt Protein Function:KIR2DL3: Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis. Belongs to the immunoglobulin superfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Receptor, misc.

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function:protein binding; receptor activity; antigen binding

Biological Process: regulation of immune response; immune response

NCBI Summary:Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
UniProt Code:P43628
NCBI GenInfo Identifier:1171727
NCBI Gene ID:3804
NCBI Accession:P43628.1
UniProt Related Accession:P43628
Molecular Weight:45kDa
NCBI Full Name:Killer cell immunoglobulin-like receptor 2DL3
NCBI Synonym Full Names:killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3
NCBI Official Symbol:KIR2DL3  
NCBI Official Synonym Symbols:p58; NKAT; GL183; NKAT2; CD158b; KIR2DL; NKAT2A; NKAT2B; CD158B2; KIR-K7b; KIR-K7c; KIR2DS5; KIRCL23; KIR-023GB  
NCBI Protein Information:killer cell immunoglobulin-like receptor 2DL3
UniProt Protein Name:Killer cell immunoglobulin-like receptor 2DL3
UniProt Synonym Protein Names:CD158 antigen-like family member B2; KIR-023GB; Killer inhibitory receptor cl 2-3; MHC class I NK cell receptor; NKAT2a; NKAT2b; Natural killer-associated transcript 2; NKAT-2; p58 natural killer cell receptor clone CL-6; p58 NK receptor CL-6; p58.2 MHC class-I-specific NK receptor; CD_antigen: CD158b2
Protein Family:Killer cell immunoglobulin-like receptor
UniProt Gene Name:KIR2DL3  
UniProt Entry Name:KI2L3_HUMAN