Various members of the low-density lipoprotein receptor (LDLR) family have been reported to play a role in APP trafficking and processing and are important risk factors in AD.LDLR-related protein 1 (LRP1) shuttles between the trans-Golgi Network (TGN); plasma membrane (PM); and endosomes.LRP1 is a functional APP receptor involved in APP trafficking and processing. LRP1 interacts directly with the ectodomain of APP and colocalizes with APP at the TGN. LRP1 is a novel APP sorting receptor that protects APP from amyloidogenic processing; suggesting that a decrease in LRP1 function may contribute to the pathogenesis of Alzheimer's disease.
Product Name:
Human LRP10 Recombinant Protein (RPES4325)
Product Code:
RPES4325
Size:
100 µg
Species:
Human
Expressed Host:
HEK293 Cells
Synonyms:
LRP9,MST087,MSTP087
Accession:
Q7Z4F1-1
Sequence:
Met 1-Lys 440
Fusion tag:
C-His
Endotoxin:
<1.0 EU per µg of the protein as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the human LRP10 (Q7Z4F1-1) extracellular domain (Met 1-Lys 440) was fused with a polyhistidine tag at the C-terminus.
Purity:
> 97 % as determined by reducing SDS-PAGE.
Mol Mass:
47.5kDa
AP Mol Mass:
60 kDa
Formulation:
Lyophilized from sterile PBS; pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
