The NME1 gene was discovered as a result of low mRNA transcript levels in highly metastatic cells. The nucleoside diphosphate kinase (NDK) is a hexamer composed of variants 'A' and 'B,' which are encoded by the NME2 gene. Mutation of the NME1 gene has been linked to aggressive neuroblastomas. Due to the work of NME1 and its adjacent gene (NME2), naturally occurring transcripts are produced, which combine portions of each individual protein product. NME1 is linked to two types of cancer: NME1 Anal Canal Carcinoma and Larynx Cancer. The pyrimidine deoxyribonucleotide de novo synthesis superpathway, the zidovudine pathway and the pharmacokinetics/pharmacodynamics are pathways linked to NME1. Human NME1/NDKA Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Human NME1/NDKA Recombinant Protein (RPES0826)
Product Code:
RPES0826
Size:
10µg
Species:
Human
Expressed Host:
E.coli
Synonyms:
Nucleoside Diphosphate Kinase A, NDK A, NDP Kinase A, Granzyme A-Activated DNase, GAAD, Metastasis Inhibition Factor nm23, Tumor Metastatic Process-Associated Protein, nm23-H1, NME1, NDPKA, NM23,AWD,GAAD,NB,NBS,NDKA,NDPK-A,NM23-H1
Accession:
P15531
Sequence:
Met 1-Glu152
Fusion tag:
N-6His
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human Nucleoside Diphosphate Kinase A is produced by our E.coli expression system and the target gene encoding Met1-Glu152 is expressed with a 6His tag at the N-terminus.
Purity:
> 90 % as determined by reducing SDS-PAGE.
Mol Mass:
19.3 kDa
AP Mol Mass:
20 kDa
Formulation:
Supplied as a 0.2 µm filtered solution of 20mM TrisHCl, 1mM DTT, 10% Glycerol, pH 7.5.
Shipping:
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
Stability and Storage:
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
