This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and four transcript variants, all encoding the same protein, have been identified.
Product Name:
Human NUDT2/Ap4A hydrolase Recombinant Protein (RPES2533)
Product Code:
RPES2533
Size:
100 µg
Species:
Human
Expressed Host:
E.coli
Synonyms:
APAH1
Accession:
P50583
Sequence:
Met 1-Ala 147
Fusion tag:
N-His
Endotoxin:
Please contact us for more information.
Protein Construction:
A DNA sequence encoding the human NUDT2 (P50583) (Met 1-Ala 147) was expressed, with a polyhistide tag at the N-terminus.
Purity:
> 97 % as determined by reducing SDS-PAGE.
Mol Mass:
18.3 kDa
AP Mol Mass:
20 kDa
Formulation:
Lyophilized from sterile PBS, pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
