Protein-Arginine Deiminase Type-4 (PADI4) belongs to the Protein Arginine Deiminase family. PADI4 is expressed in eosinophils and neutrophils, but it is not expressed in peripheral monocytes or lymphocytes. PADI4 catalyzes the citrullination/deimination of arginine residues of proteins. In addition, PADI4 may play an important role in tumourigenesis. Genetic variations in PADI4 are a cause of susceptibility to rheumatoid arthritis (RA), which is a systemic inflammatory disease with autoimmune features and a complex genetic component.
Product Name:
Human PADI4 Recombinant Protein (RPES3365)
Product Code:
RPES3365
Size:
10µg
Species:
Human
Expressed Host:
E.coli
Synonyms:
Protein-Arginine Deiminase Type-4, HL-60 PAD, Peptidylarginine Deiminase IV, Protein-arginine Deiminase type IV, PADI4, PADI5, PDI5
Accession:
Q9UM07
Sequence:
Met 1-Pro663
Fusion tag:
N-6His
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human Protein-Arginine Deiminase Type-4 is produced by our E.coli expression system and the target gene encoding Met1-Pro663 is expressed with a 6His tag at the N-terminus.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
76.2 kDa
AP Mol Mass:
78 kDa
Formulation:
Supplied as a 0.2 µm filtered solution of 50mM Tris, 500mM NaCl, pH 7.5.
Shipping:
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
Stability and Storage:
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
