Description
Recombinant Human PCBP1 Protein
The Recombinant Human PCBP1 Protein is a biologically active recombinant protein that plays a significant role in various cellular processes and signaling pathways in human biology. This protein is widely employed in immunological research, cell biology studies, protein-protein interaction analyses, and therapeutic development, providing researchers with a reliable tool for investigating PCBP1 function and its implications in health and disease.
This product (SKU: RPCB2134) is produced using E. coli and features a N-His tag for convenient detection and purification. The protein exhibits a calculated molecular weight of 38.3 kDa with an observed molecular weight of 42 kDa under denaturing conditions, achieving ≥ 85 % as determined by SDS-PAGE., ensuring exceptional quality and consistency for research applications.
Key Features
| High Purity by Affinity Chromatography | |
| Mammalian & Bacterial Expression Systems | |
| High lot-to-lot consistency via strict QC |
| Product Name: | Recombinant Human PCBP1 Protein |
| SKU: | RPCB2134 |
| Size: | 100 μg |
| Reactivity: | Human |
| Synonyms: | HNRPX, HNRPE1, hnRNP-X, HEL-S-85, hnRNP-E1, PCBP1 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Calculated MW: | 38.3 kDa |
| Observed MW: | 42 kDa |
| Gene ID: | 5093 |
| Protein Description: | High quality, high purity and low endotoxin recombinant Recombinant Human PCBP1 Protein (RP03165LQ), tested reactivity in E. coli and has been validated in SDS-PAGE.100% guaranteed. |
| Endotoxin: | Please contact us for more information. |
| Purity: | ≥ 85 % as determined by SDS-PAGE. |
| Formulation: | Supplied as sterile 50mM Tris, 500mM NaCl, 20% glycerol, pH 8.0 |
| Storage: | Store at -70℃. This product is stable at ≤ -70℃ for up to 1 year from the date of receipt. For optimal storage, aliquot into smaller quantities after centrifugation and store at recommended temperature. Avoid repeated freeze-thaw cycles. |
Poly(rC)-binding protein 1, also known as Heterogeneous nuclear ribonucleoprotein E1, Alpha-CP1, Nucleic acid-binding protein SUB2.3 and PCBP1, is a family member of heterogeneous nuclear ribonucleoproteins (hnRNPs) that belong to RNA-binding proteins and bear three KH domains. PCBP1 is loosely bound in the nucleus. It may shuttle between the nucleus and the cytoplasm. It is abundantly expressed in skeletal muscle, thymus and peripheral blood leukocytes while a lower expression is observed in prostate, spleen, testis, ovary, small intestine, heart, liver, adrenal and thyroid glands. PCBP1 is widely expressed in many human tissues and involved in the regulation of transcription, transportation process, and function of RNA molecules. PCBP1 plays a pivotal role in post-transcriptional regulation for RNA metabolism and RNA function in gene expression. PCBP1 acts as a negative regulator of CD44 variants splicing in HepG2 cells, and loss of PCBP1 in human hepatic tumor contributes to the formation of a metastatic phenotype.
 | Recombinant Human PCBP1 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue. |
